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  • Title: bcl-xs gene therapy induces apoptosis of human mammary tumors in nude mice.
    Author: Ealovega MW, McGinnis PK, Sumantran VN, Clarke MF, Wicha MS.
    Journal: Cancer Res; 1996 May 01; 56(9):1965-9. PubMed ID: 8616832.
    Abstract:
    Bcl-xs is a dominant negative repressor of Bcl-2 and Bcl-xL, both of which inhibit apoptosis. We used a replication-deficient adenoviral vector to transiently overexpress Bcl-xs in MCF-7 human breast cancer cells, which overexpress Bcl-xL. Infection with this vector induced apoptosis in vitro. We then determined the effects of intratumoral injection of bcl-xs adenovirus on solid MCF-7 tumors in nude mice. Tumors injected four times with the bcl-xs adenovirus showed a 50% reduction in size. Using terminal transferase-mediated dUTP-digoxigenin nick end labeling, we observed apoptotic cells at sites of bcl-xs adenoviral injection. These experiments demonstrate the feasibility of using bcl-xs gene therapy to induce apoptosis in human breast tumors.
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