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  • Title: Cloning of a potential cytochrome P450 from the archaeon Sulfolobus solfataricus.
    Author: Wright RL, Harris K, Solow B, White RH, Kennelly PJ.
    Journal: FEBS Lett; 1996 Apr 22; 384(3):235-9. PubMed ID: 8617361.
    Abstract:
    Abstract A gene, CYP119, for a potential cytochrome P450 has been isolated and sequenced from the extreme acidothermophilic archaeon Sulfolobus solfataricus. The gene predicts a polypeptide of 368 amino acids containing the consensus heme-binding sequence Phe-Gly-Xaa-Gly-Xaa-His-Xaa-Cys-Xaa-Gly- Xaa3-Ala-Arg-Xaa-Glu. It most closely resembles the cytochrome P450s found in the bacterium Bacillus subtilis, with which it shares 129 identical amino acid residues (35%). This first sequence of a potential archaeal cytochrome P450 represents an important step in tracing the complex evolutionary history of this biologically important enzyme family.
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