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  • Title: Glycated Cu,Zn-superoxide dismutase in rat lenses: evidence for the presence of fragmentation in vivo.
    Author: Takata I, Kawamura N, Myint T, Miyazawa N, Suzuki K, Maruyama N, Mino M, Taniguchi N.
    Journal: Biochem Biophys Res Commun; 1996 Feb 06; 219(1):243-8. PubMed ID: 8619815.
    Abstract:
    Cu,Zn-superoxide dismutase (Cu,Zn-SOD) exists in tissues of rats as both glycated and non-glycated forms when separated by boronate acid column chromatography. Glycated Cu.Zn-SOD is most abundant in rat lenses compared to other tissues. In normal rats lens levels of glycated Cu.Zn-SOD showed a gradual increase with age, whereas in diabetic rats substantial increases were observed. Immunoblotting analyses, using anti-hexitol lysine IgG, indicated that glycated Cu.Zn-SOD contains Amadori products. Moreover, Cu.Zn-SOD in lenses was site-specifically fragmented probably because of glycation. This the first report of a fragmented protein, such as Cu,Zn-SOD, occurring in vivo.
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