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  • Title: Freeze-fracture analysis of junctional complexes in the nephron of the garter snake, Thamnophis sirtalis.
    Author: Peek WD, Shivers RR, McMillan DB.
    Journal: Cell Tissue Res; 1977 Apr 29; 179(4):441-51. PubMed ID: 862009.
    Abstract:
    Zonulae occludentes are shown by freeze-fracture to be pleomorphic along the garter snake nephron. In the neck and proximal segments the occluding junctions are moderately complex with frequent discontinuities in their junctional fibrils. Junctional depth and complexity are maximal in the distal and collecting segments and discontinuities in fibrils are absent. Comparison of these results with similar observations on other tissues indicates that the zonulae occludentes in the neck and proximal segments are "intermediate" to "leaky" and that they may be "very light" in the distal and collecting segments. The findings suggest that in the garter snake nephron transepithelial flow of fluid may occur primarily by passive diffusion through the zonulae occludentes in the neck and proximal segments and by cell-mediated osmotic flow in the distal and collecting segments. Gap junctions occur only in the proximal tubule and areprobably involved in low resistance, intercellular movement of ions.
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