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  • Title: A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier.
    Author: Xiang ZQ, Yang Y, Wilson JM, Ertl HC.
    Journal: Virology; 1996 May 01; 219(1):220-7. PubMed ID: 8623532.
    Abstract:
    In this manuscript, an E1 and E3 deleted adenoviral recombinant expressing the rabies virus glycoprotein (G protein) under the control of the cytomegalovirus early promoter was tested for induction of a rabies virus-specific immune response in mice. The construct was found to induce neutralizing antibodies and cytolytic T cells to rabies virus. Mice vaccinated with the adenoviral construct either by the systemic route or by application into the airways were protected against a subsequent infection with a virulent strain of rabies virus. The efficacy of the replication-defective construct was far superior to that of a well-characterized vaccinia rabies glycoprotein recombinant.
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