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  • Title: The role of interleukin-4 in the regulation of mouse primordial germ cell numbers.
    Author: Cooke JE, Heasman J, Wylie CC.
    Journal: Dev Biol; 1996 Feb 25; 174(1):14-21. PubMed ID: 8626013.
    Abstract:
    Interleukin-4 (IL-4), a pleiotropic cytokine, stimulates a dose-dependent increase in the number of mouse primordial germ cells in culture. Results from bromodeoxyuridine incorporation assays suggest that IL-4 acts as a survival factor rather than as a mitogen for primordial germ cells in this system. Studies on the embryonic expression patterns of IL-4 and its receptors, using RT-PCR and ELISA, show that IL-4 and its receptors are present at the correct time and place to influence PGC numbers in vivo.
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