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  • Title: Conjugated bilirubin in neonates with glucose-6-phosphate dehydrogenase deficiency.
    Author: Kaplan M, Rubaltelli FF, Hammerman C, Vilei MT, Leiter C, Abramov A, Muraca M.
    Journal: J Pediatr; 1996 May; 128(5 Pt 1):695-7. PubMed ID: 8627445.
    Abstract:
    We used a system capable of measuring conjugated bilirubin and its monoconjugated and diconjugated fractions in serum to assess bilirubin conjugation in 29 glucose-6-phosphate dehydrogenase (G6PD)-deficient, term, male newborn infants and 35 control subjects; all had serum bilirubin levels > or = 256 mumol/L (15 mg/dI). The median value for diconjugated bilirubin was lower in the G6PD-deficient neonates than in control subjects (0.06 (range 0.00 to 1.84) vs 0.21 (range 0.00 to 1.02) mumol/L, p = 0.006). Diglucuronide was undetectable in 11 (38.9%) of the G6PD-deficient infants versus 3 (8.6%) of the control subjects (p = 0.015). These findings imply a partial defect of bilirubin conjugation not previously demonstrated in G6PD-deficient newborn infants.
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