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  • Title: In vitro activity of imipenem and six other beta-lactam antibiotics against aminoglycoside resistant gram-negative bacilli.
    Author: Bujdáková H, Kallová J, Lausová A, Kettner M.
    Journal: Microbios; 1995; 84(339):87-90. PubMed ID: 8628124.
    Abstract:
    The in vitro activity of imipenem and six other beta-lactams (ampicillin, cefamandole, cefoxitin, ceftriaxone, ceftazidime, cefotaxime) against twenty Gram-negative bacilli resistant to clinically important aminoglycosides was studied. The bacterial strains showed high resistance (R) to gentamicin, tobramycin (R 100%), netilmicin (R 75%) and to the beta-lactams ampicillin (R 100%), cephamandole (R 90%) and cefoxitin (R 75%). The strains were susceptible to isepamicin (R 10%) and imipenem (R 10%) as well as susceptible to at least third generation cephalosporin. Three Pseudomonas aeruginosa strains were resistant to the majority of antibiotics, except for imipenem.
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