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  • Title: [The diagnostic significance of blast immunophenotype assay in patients with acute leukemia].
    Author: Piatoska-Jakubas B, Pituch-Noworolska A, Skotnicki AB, Balana-Nowak A.
    Journal: Acta Haematol Pol; 1996; 27(1):33-41. PubMed ID: 8629441.
    Abstract:
    A detailed analysis of immunophenotypes of 120 adult newly diagnosed patients with acute leukaemias was performed. Using the immunopheno-typing, it was possible to defined 96,7% of leukemia cases. The proportion of leukemia subtypes was: AML in 62,5%, ALL in 32,5%, acute biphenotypic leukaemia 1,7% and acute undifferentiated leukaemia (AUL) in 3,3%. The diagnosis initially made according FAB criterias in 12,5% cases after the immunophenotyping was verified. Above analyses showed the existence of the atypical blasts phenotypes in 31%: co-expression of CD 19, CD2 and CD7 markers in AML, co-expression of CD 33 marker in ALL, co-expression of CD 19 marker in T cell ALL and biphenotypic (mixed-lineage) leukaemia.
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