These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Anti-TNF treatment reverts increased muscle ubiquitin gene expression in tumour-bearing rats.
    Author: Llovera M, Carbó N, García-Martínez C, Costelli P, Tessitore L, Baccino FM, Agell N, Bagby GJ, López-Soriano FJ, Argilés JM.
    Journal: Biochem Biophys Res Commun; 1996 Apr 25; 221(3):653-5. PubMed ID: 8630016.
    Abstract:
    Implantation of the ascitic tumour Yoshida AH-130 hepatoma (a cachectic tumour) resulted in important increases in muscle ubiquitin gene expression. Administration of daily injections of 25 mg/kg b.w. polyclonal goat anti-murine TNF IgG preparation to tumour-bearing rats abolished the increase in muscle ubiquitin gene expression observed in the control (non-anti-TNF-treated) tumour-bearing rats. It is concluded that TNF can have an important role in the activation of the ubiquitin-dependent proteolytic system during tumour growth.
    [Abstract] [Full Text] [Related] [New Search]