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  • Title: Involvement of the oxidative pentose phosphate pathway in thiamine biosynthesis in Salmonella typhimurium.
    Author: Enos-Berlage JL, Downs DM.
    Journal: J Bacteriol; 1996 Mar; 178(5):1476-9. PubMed ID: 8631729.
    Abstract:
    purF mutants of Salmonella typhimurium are known to require a source of both purine and thiamine; however, exogenous pantothenate may be substituted for the thiamine requirement. We show here that the effect of pantothenate is prevented by blocks in the oxidative pentose phosphate pathway, gnd (encoding gluconate 6-phosphate [6-P] dehydrogenase) or zwf (encoding glucose 6-P dehydrogenase). We further show that the defects caused by these mutations can be overcome by increasing ribose 5-P, suggesting that ribose 5-P may play a role in the ability of pantothenate to substitute for thiamine.
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