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  • Title: Brush border enzymes in evaluation of acute small bowel rejection.
    Author: Kuusanmäki P, Lauronen J, Paavonen T, Pakarinen M, Savilahti E, Häyry P, Halttunen J.
    Journal: Scand J Immunol; 1996 May; 43(5):566-73. PubMed ID: 8633216.
    Abstract:
    The change in activity of three disaccharidase enzymes (maltase, sucrase and lactase) was determined according to the method of Dahlqvist during acute rejection in non-immunosuppressed piglet small bowel grafts. In addition, two brush border enzymes, lactase and aminopeptidase, were stained with monoclonal antibodies. Diminishing disaccharidase activity was an early event during rejection. Diminution began 2 days before distinct morphological changes were seen in the mucosal biopsies. Evaluation of disaccharidase activity can thus be used as a confirmatory method in detecting rejection. Reduction in immunohistological staining of lactase and aminopeptidase with monoclonal antibodies and changes in mucosal morphology were observed to progress simultaneously.
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