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  • Title: [Radiobiologic in-vivo investigation of angiogenesis in the yolk sac vascular system of chicken embryos].
    Author: Plasswilm L, Höper J, Sauer R.
    Journal: Strahlenther Onkol; 1996 May; 172(5):260-4. PubMed ID: 8633258.
    Abstract:
    PURPOSE: The aim of this study was to investigate whether the yolk sac blood vessel system of chick embryos represents a useful model of in-vivo measurements of angiogenesis in radiobiology. MATERIAL AND METHODS: The fertilized eggs of the crossbreeding White Plymouth Rox X Sussex were used for the study of the extraembryonic vascularisation after irradiation with different fractionation and dosage. On day 3 of incubation an oval window was cut into the shell and then the area vasculosa was irradiated with 1.0 cm in diameter. Forty-eight hours after irradiation in-vivo photographs were taken for quantitative evaluation of blood vessel density. RESULTS: Irradiation from 2.0 to 8.0 Gy in a single fraction leads to a slight decrease in vascular density. After a single fraction of 10.0 Gy a distinct increase in vascular density occurs. Fractionated irradiation leads to a considerable clear increasing of vascular density in comparison with the single fraction and same total dose. CONCLUSION: Our model of the fertilized egg enables in-vivo measurements of angiogenesis in radiobiology.
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