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  • Title: Radioassay of soluble immune complexes using their uptake by macrophage Fc receptors.
    Author: Kávai M, Dankó K, Kalmár E, Francia I, Szegedi G.
    Journal: Immunology; 1977 May; 32(5):617-21. PubMed ID: 863474.
    Abstract:
    Sera from patients were tested for the presence of soluble immune complexes (IC) by a method based on the observation that IC inhibit uptake of aggregated IgG by the Fc receptors of macrophages. From the saturation curve of macrophages with 125I-labelled aggregates the optimal inhibitory effect of a measured amount of IC was determined. This radioassay is highly sensitive, being capable of detecting 20 ng of IC, is reproducible and covers a wide range of measurement (20-2000 ng).
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