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  • Title: Selective IgA deficiency and anaphylactoid transfusion reaction: a case report.
    Author: Wei CH, Lin M, Hsieh RK, Tzeng CH, Liu JH, Fan S, Chiou TJ, Chen PM.
    Journal: Zhonghua Yi Xue Za Zhi (Taipei); 1996 Feb; 57(2):165-8. PubMed ID: 8634934.
    Abstract:
    Anaphylactoid transfusion reaction following the administration of incompatible blood products can be life threatening, but accounts for only a very small proportion of all transfusion reactions. One of the causes of anaphylactoid transfusion reaction is the reaction of patient's anti-immunoglobulin A(IgA) with plasma IgA which is usually present in transfused blood. We report a case who had anaphylactoid transfusion reactions after transfusion of only a few milliliters of packed RBC from 3 consecutive donors, in spite of compatible pretransfusion crossmatches. The patient's serum revealed IgA deficiency accompanied by high-titer anti-IgA. The family study showed that one of her sons had partial IgA deficiency accompanied by anti-IgA2. In conclusion, although selective IgA deficiency is rare in Taiwan, it may still occasionally result in severe anaphylactoid transfusion reactions.
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