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  • Title: GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport.
    Author: Subramaniam VN, Peter F, Philp R, Wong SH, Hong W.
    Journal: Science; 1996 May 24; 272(5265):1161-3. PubMed ID: 8638159.
    Abstract:
    Little is known about the integral membrane proteins that participate in the early secretory pathway of mammalian cells. The complementary DNA encoding a 28-kilodalton protein (p28) of the cis-Golgi was cloned and sequenced. The protein was predicted to contain a central coiled-coil domain with a carboxyl-terminal membrane anchor. An in vitro assay for endoplasmic reticulum-Golgi transport was used to show that p28 participates in the docking and fusion stage of this transport event. Biochemical studies established that p28 is a core component of the Golgi SNAP receptor (SNARE) complex.
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