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  • Title: BCR rearrangement without juxtaposition of ABL in pre-T acute lymphoblastic leukaemia.
    Author: Fosså A, Siebert R, Kasper C, Becher R, Opalka B, Thiel E, Seeber S, Nowrousian MR.
    Journal: Br J Haematol; 1996 May; 93(2):403-5. PubMed ID: 8639438.
    Abstract:
    The incidence and clinical relevance of the Philadelphia (Ph) translocation t(9:22) (q34:q11) in T-lineage acute lymphoblastic leukaemia (ALL) are unknown. We describe a patient with pre-T-ALL and a clonal 22q-aberration detected by conventional cytogenetics, suggestive of a Ph translocation. However, fluorescence in situ hybridization (FISH) using BCR and ABL probes revealed a translocation with one breakpoint within the BCR gene on chromosome 22 without juxtaposition of ABL on chromosome 9. We discuss the diagnostic and possible pathogenetic implications of this Ph-like chromosomal aberration.
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