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  • Title: Fulminant adenovirus hepatitis after allogeneic bone marrow transplantation.
    Author: Bertheau P, Parquet N, Ferchal F, Gluckman E, Brocheriou C.
    Journal: Bone Marrow Transplant; 1996 Feb; 17(2):295-8. PubMed ID: 8640184.
    Abstract:
    Adenoviruses may cause severe infections in bone marrow transplant recipients. We report the case of a patient who developed fulminant hepatitis 5 months after bone marrow transplantation. Adenovirus type 2 was cultured from stool and blood samples. The patient died from liver failure. Histologic examination of post-mortem liver samples showed extensive necrosis with nuclear inclusions. Adenovirus was identified in liver cells by electron microscopy and immunohistochemical staining using a monoclonal anti-adenovirus antibody. No other pathogen was identified.
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