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  • Title: Comparison of concentrations of amoxicillin and ampicillin in serum and middle ear fluid of children with chronic otitis media.
    Author: Klimek JJ, Nightingale C, Lehmann WB, Quintiliani R.
    Journal: J Infect Dis; 1977 Jun; 135(6):999-1002. PubMed ID: 864293.
    Abstract:
    Twenty-eight children aged five to nine years with chronic serous otitis media received a single dose of either ampicillin or amoxicillin by the oral route 1-2 hr before the removal of middle ear fluid by ventilation tubes inserted through the tympanic membrane. At the time middle ear fluid was obtained, a sample of blood was drawn from the patient, and levels of antibiotic in both specimens were microbiologically assayed by a disk diffusion method. Levels of amoxicillin (mean+/-standard error [SE], 1.48+/-1.6 microng/ml) in middle ear fluid were consistently and significantly higher (P less than 0.05) than levels of ampicillin (mean+/-SE, 6.2+/-5.0 microng/ml).
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