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  • Title: Protein recognition of a ribosomal RNA tertiary structure.
    Author: Draper DE, Xing Y.
    Journal: Nucleic Acids Symp Ser; 1995; (33):5-7. PubMed ID: 8643396.
    Abstract:
    Ribosomal protein L11 recognizes a highly conserved, 58 nucleotide domain of large subunit ribosomal RNA. This domain has a set of tertiary interactions that are specifically stabilized by Mg2+ and NH4+ ions. The protein recognizes this tertiary structure, in the sense that ions stabilizing the tertiary structure also promote L11 binding, and a heat stable form of the protein (from Bacillus stearothermophilus) prevents RNA unfolding. We also find that these RNA-binding properties are confined to a approximately 75 amino acid domain of the protein. The larger issue of L11 function within the ribosome is discussed in light of these findings.
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