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  • Title: Crystal structure of a human TATA box-binding protein/TATA element complex.
    Author: Nikolov DB, Chen H, Halay ED, Hoffman A, Roeder RG, Burley SK.
    Journal: Proc Natl Acad Sci U S A; 1996 May 14; 93(10):4862-7. PubMed ID: 8643494.
    Abstract:
    The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.
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