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  • Title: Combination regimens of paclitaxel and the platinum drugs as first-line regimens for ovarian cancer.
    Author: Ozols RF.
    Journal: Semin Oncol; 1995 Dec; 22(6 Suppl 15):1-6. PubMed ID: 8643963.
    Abstract:
    A platinum compound combined with paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has supplanted a platinum compound and cyclophosphamide as standard chemotherapy in the United States for patients with previously untreated ovarian cancer. Numerous studies are under way to determine the optimal use of these drugs as first-line treatment. Among the critical issues being explored are the length of the paclitaxel infusion, the optimum number of cycles, and paclitaxel dose intensity. The Gynecologic Oncology Group is pursuing studies of paclitaxel and carboplatin, based on promising results from a phase I/II study. Carboplatin is equivalent to cisplatin in terms of efficacy, but has only myelosuppression as a dose-limiting toxicity. Other novel approaches being investigated in ongoing Gynecologic Oncology Group trials include an evaluation of interval debulking surgery as one arm of a trial in which patients with suboptimal stage III and IV disease are receiving paclitaxel/cisplatin.
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