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  • Title: Human chorionic gonadotropin produced by ectopic pinealoma in a girl with precocious puberty. Case report.
    Author: Kubo O, Yamasaki N, Kamijo Y, Amano K, Kitamura K, Demura R.
    Journal: J Neurosurg; 1977 Jul; 47(1):101-5. PubMed ID: 864495.
    Abstract:
    A case is reported in which a human chorionic gonadotropin (HCG-)-producing ectopic pinealoma was found in a 5-year-old girl with precocious puberty. Physical examination revealed abnormal breast enlargement. Endocrinological study disclosed a high plasma HCG concentration of 1192 ng/ml with a normal follicular stimulating hormone (FSH) level. The HCG content of the tumor was as high as 400 ng/mg of acetone dried tissue, but no FSH was detectable. This is the first reported case of precocious puberty associated with pineal tumor in a female.
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