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  • Title: [Effect of antibiotics on glucocorticoid receptor function].
    Author: Golikov PP.
    Journal: Antibiot Khimioter; 1995 Jul; 40(7):25-9. PubMed ID: 8645055.
    Abstract:
    The effects of penicillin G and cefazolin (cefamezin) on the function of the types II and III glucocorticoid receptors of the liver cytosol were studied on Wistar male rats weighing 180-200 g. The Scatchard and Lineweaver--Berk analysis showed that penicillin G and cefazolin (0.1-10.0 mM) induced a dose-dependent increase in the density of the type III glucocorticoid receptors and a decrease in the affinity of 3H-corticosterone with the type III glucocorticoid receptors. The activation of the function of the type III glucocorticoid receptor by penicillin G and cefazolin was not competitive. Penicillin G had no significant effect on the function of the type II glucocorticoid receptors. The increase in the density of the type II glucocorticoid receptors under the effect of cefazolin was dose-dependent though Ka and Kd did not significantly change. The results were indicative of the fact that penicillins and cephalosporins had a strong action on the most important regulatory system of homeostasis, i.e. the glucocorticoid function which is the decisive one in the pathogenesis of inflammation.
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