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  • Title: Plasma GABA predicts acute response to divalproex in mania.
    Author: Petty F, Rush AJ, Davis JM, Calabrese JR, Kimmel SE, Kramer GL, Small JG, Miller MJ, Swann AE, Orsulak PJ, Blake ME, Bowden CL.
    Journal: Biol Psychiatry; 1996 Feb 15; 39(4):278-84. PubMed ID: 8645774.
    Abstract:
    Bipolar I, manic phase inpatients were treated with divalproex sodium, lithium, or placebo in a previously reported parallel group multicenter, double-blind, randomized, controlled acute phase treatment trial. Plasma concentrations of gamma aminobutyric acid (GABA) were measured before and after treatment. Higher pretreatment plasma GABA levels were significantly (p = .04) related to a better clinical response to divalproex (n = 19). Pretreatment plasma GABA levels did not correlate with response to either lithium (n = 13) or placebo (n = 31). Following treatment with divalproex sodium, plasma GABA levels decreased significantly (p < .05), compared to placebo. Pretreatment plasma GABA levels were not related to overall severity of manic symptoms. Plasma GABA may predict response to pharmacologic agents acting on the GABA system.
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