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  • Title: Hepatic mixed-function oxidase activity in mice treated with methylated benzenes and methylated naphthalenes.
    Author: Fabacher DL, Hodgson E.
    Journal: J Toxicol Environ Health; 1977 May; 2(5):1143-6. PubMed ID: 864785.
    Abstract:
    Eight methylated benzene and five methylated naphthalene compounds were injected ip into adult male mice daily for 3 days. On the fourth day livers from control and treated mice were compared with regard to weight, microsomal N- and O-demethylase activity, and various spectral characteristics of microsomal cytochrome P-450. Three methylated benzenes and one methylated naphthalene produced significant increases in liver weight/body weight ratios, O-demethylation of p-nitroanisole, N-demethylation of aminopyrene, or a combination of these.
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