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  • Title: Epsilon 4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population.
    Author: Hong CJ, Liu TY, Liu HC, Wang SJ, Fuh JL, Chi CW, Lee KY, Sim CB.
    Journal: Neurology; 1996 Jun; 46(6):1749-51. PubMed ID: 8649585.
    Abstract:
    We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of epsilon 4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two epsilon 4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of epsilon 4 was also significant (chi 2 = 8.2, p = 0.004). Our results support the association between epsilon 4 and AD in the Chinese.
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