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  • Title: [Molecular analysis of the heterogeneity of hereditary monosymptomatic sensorineural hearing loss].
    Author: Fiegert P, Lamprecht-Dinnesen A, Preisler-Adams S, Deufel T.
    Journal: Laryngorhinootologie; 1996 Mar; 75(3):141-7. PubMed ID: 8652029.
    Abstract:
    BACKGROUND: Genetic characterization of hereditary hearing impairment has progressed considerably with the mapping of nine chromosomal loci for monosymptomatic autosomal-inherited hearing loss over the last three years. METHODS: Following thorough clinical evaluation, linkage analysis using microsatellite markers was performed in two large families from Westphalia/West Germany. RESULTS: For all the dominant (DFNA1--4) and three autosomal-recessive loci (DFNB1--3) described to date, linkage was finally excluded. CONCLUSIONS: A high degree of genetic heterogeneity must be assumed. Identification of individual genes for monosymptomatic sensorineural hearing loss by linkage analysis in large pedigrees may help in molecular differentiation of hearing.
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