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  • Title: Mediators of fibrinolysis in orthotopic liver transplantation.
    Author: Cheema SP, Webster NR, Dunn F, Bellamy MC.
    Journal: Clin Transplant; 1996 Feb; 10(1 Pt 1):24-7. PubMed ID: 8652893.
    Abstract:
    Activation of fibrinolysis remains a clinical problem in orthotopic liver transplantation. We have measured tissue plasminogen activator (t-PA), plasmin and alpha-2-anti-plasmin (alpha 2AP) activities in plasma from 10 patients undergoing elective transplantation. t-PA activity increased during the anhepatic phase and immediately after graft reperfusion (p > 0.001). This increase could not be attributed to t-PA released by the donor liver. Overall transfusion requirements did not relate with either t-PA or alpha 2AP activities individually, but were strongly correlated with the ratio t-PA/ alpha 2AP (p > 0.02). These results suggest that routine prophylactic use of antifibrinolytic agents may be beneficial.
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