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  • Title: [Isovolemic hemodilution for avoiding homologous blood transfusions: effectiveness in large gynecologic interventions].
    Author: Oberhauser M, Bardenheuer HJ, Bernasconi H, Genz T, Kreimeier U.
    Journal: Infusionsther Transfusionsmed; 1996 Feb; 23(1):15-23. PubMed ID: 8653011.
    Abstract:
    OBJECTIVE: The practicability and efficiency of a standardized, preoperative isovolemic hemodilution was investigated during major gynecological operations (Wertheim's operation, etc.). DESIGN: Prospective clinical trial with a historical control group. SETTING: Operating room of a gynecological university hospital. PATIENTS AND INTERVENTIONS: Under general anesthesia hemodilution to a hemoglobin concentration of 9 g/dl was performed in 48 patients (mean age: 53 years). Shed blood volume amounted to 900 +/- 210 ml. Transfusion of autologous or homologous blood was provided when Hb concentration decreased beyond 7 g/dl intraoperatively. RESULTS: Compared to a control group of 57 patients without hemodilution the total number of PRBC units transfused was significantly reduced. Moreover, in 65% of all patients the transfusion of homologous blood could completely be avoided perioperatively (control group: 21% of patients). Adverse effects did not occur. CONCLUSIONS: The data reflect that acute isovolemic hemodilution before major gynecological operations represents a safe, easy to handle and effective procedure to avoid transfusion of homologous blood up to a total blood loss of 1,300-1,400 ml.
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