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  • Title: The Bcl I polymorphism of the human uncoupling protein (ucp) gene is due to a point mutation in the 5'-flanking region.
    Author: Cassard-Doulcier AM, Bouillaud F, Chagnon M, Gelly C, Dionne FT, Oppert JM, Bouchard C, Chagnon Y, Ricquier D.
    Journal: Int J Obes Relat Metab Disord; 1996 Mar; 20(3):278-9. PubMed ID: 8653151.
    Abstract:
    The polymorphic Bcl I site in the human ucp gene associated to percentage fat gain over time in the Québec Family Study cohort (Oppert et al. Int J Obesity 1994; 18: 526-531) has been positioned to the 5'-flanking region. This polymorphism results from a unique A/G mutation. Oligonucleotides used to amplify the polymorphic region, and allowing future studies of any cohort of patients, are described.
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