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  • Title: Squamous cell carcinoma arising in dermoid cyst.
    Author: Ayhan A, Tuncer ZS, Bilgin F, Küçükali T.
    Journal: Eur J Gynaecol Oncol; 1996; 17(2):144-7. PubMed ID: 8654472.
    Abstract:
    Since malignant transformation in a dermoid cyst is extremely rare, the clinicopathological characteristics of patients with squamous carcinoma arising in dermoid cyst are evaluated in the hope of offering a more rational therapy. Our first patient was lost to follow-up after surgery. In the second patient, with a gross stage III disease, after extensive surgery and multiagent chemotherapy we were able to achieve a remission period of 42 months. In the third patient with pelvic lymph node metastases, adjuvant radiation and chemotherapy was administered following surgical staging. She was free of disease 6 months after surgery. Malignant transformation in a dermoid cyst is a rare complication observed especially in older age groups. Thus, a frozen section in these decades may improve detection of this complication allowing a more accurate staging. Although poor prognosis is reported, an aggressive approach with cisplatinum based chemotherapy and radiation and even with secondary cytoreduction, long-term remission may be achieved.
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