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  • Title: The effect of dose fractionation on gamma-radiation induced mutations in mammalian cells.
    Author: Asquith JC.
    Journal: Mutat Res; 1977 Apr; 43(1):91-100. PubMed ID: 865492.
    Abstract:
    The lethal and mutagenic effects of single and fractionated doses of gamma-radiation were studied in V79-4 Chinese hamster cells, as dose fractionation is of interest in radiation protection studies. The results show that the induction of 8-azaguanine resistant (Agr) mutants has a non-linear dose response curve following single doses of radiation. The lethal and mutagenic effects of fractionated doses were always less than if the radiation was given in a single dose. Any change in treatment which led to an increase in survival also led to a decrease in induced mutation frequency. There was a relationship between mutation and survival which was independent of the number of fractions in which the radiation was given. This could be of consequence in radiological protection.
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