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  • Title: Exogenous nitric oxide causes collapse of retinal ganglion cell axonal growth cones in vitro.
    Author: Rentería RC, Constantine-Paton M.
    Journal: J Neurobiol; 1996 Apr; 29(4):415-28. PubMed ID: 8656208.
    Abstract:
    We show that nitric oxide (NO) from applied NO-donating chemicals induces collapse of ganglion cell axonal growth cones extending from explants of tadpole retina in culture. Peroxynitrite, a neurotoxic product of NO and superoxide reaction, did not induce collapse, and oxyhemoglobin, which binds NO, blocked the highly effective collapsing activity of the NO donor S-nitrosocysteine. Membrane-permeable analogs of cyclic guanosine monophosphate had no collapsing activity. Inhibitors of NO synthase did not induce collapse. NO is a potential retrograde messenger through which postsynaptic neurons signal to their inputs to modify synaptic efficacy following NMDA receptor activation. Our results suggest a role for NO as such a messenger during development of the retinotectal projection.
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