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  • Title: Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans.
    Author: Hubbard EJ, Dong Q, Greenwald I.
    Journal: Science; 1996 Jul 05; 273(5271):112-5. PubMed ID: 8658178.
    Abstract:
    The Caenorhabditis elegans LIN-12 and GLP-1 proteins are members of the LIN-12/Notch family of receptors for intercellular signals that specify cell fate. Evidence presented here suggests that the intracellular domains of LIN-12 and GLP-1 interact with the C. elegans EMB-5 protein and that the emb-5 gene functions in the same pathway as the lin-12 and glp-1 genes. EMB-5 is similar in sequence to a yeast protein that controls chromatin structure. Hence, a direct consequence of LIN-12 or GLP-1 activation may be an alteration of chromatin structure that produces changes in transcriptional activity.
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