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  • Title: [Molecular changes in adenocarcinoma of the small intestine associated with Peutz-Jeghers syndrome].
    Author: Hidalgo L, Villanueva A, Soler T, Matías Guiu X, Capellá G.
    Journal: Rev Esp Enferm Dig; 1996 Feb; 88(2):137-40. PubMed ID: 8664070.
    Abstract:
    The presence of molecular alterations in the c-K-ras and p53 genes in a small bowel adenocarcinoma arising in a case of Peutz-Jeghers syndrome is reported. The absence of mutations at codon 12 and 13 of the c-K-ras gene in the hamartoma and carcinoma indicates that this oncogene does not contribute to its development. On the other hand, p53 protein overexpression was detected in a small proportion (5-10%) of adenocarcinoma cells. Our findings suggest that p53 inactivation occur in late stages of tumour progression.
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