These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Native lipoproteins inhibit platelet activation induced by oxidized lipoproteins.
    Author: Takahashi Y, Chiba H, Matsuno K, Akita H, Hui SP, Nagasaka H, Nakamura H, Kobayashi K, Tandon NN, Jamieson GA.
    Journal: Biochem Biophys Res Commun; 1996 May 15; 222(2):453-9. PubMed ID: 8670226.
    Abstract:
    Copper-catalyzed oxidation of low-density lipoproteins (LDL) (0.8 g protein/l LDL, 20 mumol/l CuSo4, 37 degrees C) resulted in the formation of thiobarbituric reactive substances that was substantially completed at 24 hrs whereas their formation from high-density lipoproteins (HDL) plateaued at only 25% of that amount after 8 hrs. The oxidized lipoproteins induced aggregation and increases in [Ca2+]i in washed platelets, but not in platelet-rich plasma, and these activating effects were not inhibited by aspirin or EGTA but were inhibited by both of the native lipoproteins. These results show that oxidized HDL, like oxidized LDL, have platelet activating ability and suggest that the native lipoproteins may play a crucial role in preventing the oxidized lipoprotein-mediated platelet activation.
    [Abstract] [Full Text] [Related] [New Search]