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  • Title: Mechanism of oxidative damage of dog kidney Na/K-ATPase.
    Author: Boldyrev A, Kurella E.
    Journal: Biochem Biophys Res Commun; 1996 May 15; 222(2):483-7. PubMed ID: 8670231.
    Abstract:
    Oxidative modification of kidney Na/K-ATPase was found to be accompanied by a decrease in the amount of sulfhydryl groups accessible for Elmann reagent with subsequent transformation of kinetic behavior of the enzyme. Oxidation of Na/K-ATPase with 20 mM hydrogen peroxide during 20 min results in about 50% inhibition of its activity and subsequent transformation of complex substrate-velocity dependence into the simple hyperbolic curve. In terms of kinetic analysis the suggestion was made that partial oxidation of Na/K-ATPase by hydrogen peroxide results in disordering of interprotomer interaction in the oligomeric complex of Na/K-ATPase.
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