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  • Title: Structural characterization of a new galactofuranose-containing glycolipid antigen of Paracoccidioides brasiliensis.
    Author: Levery SB, Toledo MS, Suzuki E, Salyan ME, Hakomori S, Straus AH, Takahashi HK.
    Journal: Biochem Biophys Res Commun; 1996 May 15; 222(2):639-45. PubMed ID: 8670257.
    Abstract:
    An acidic glycolipid (Band 1), purified from P. brasiliensis by a combination of ion exchange chromatography, HPLC, and HPTLC, was found to be reactive with sera of all patients with paracoccidioidomycosis (PCM). Monosaccharide analysis of Band 1 yielded mannose and galactose in a 2:1 ratio, while mild acid hydrolysis and mild periodate oxidation/NaB3H4 reduction indicated the presence of a terminal galactofuranose. Preliminary analysis of 1H-NMR and MS data suggests that the structure of the glycan is Galf beta 1-->6(Manp alpha 1-->3)Manp beta 1-->2Ins (Ins = myo-inositol). Removal of the galacto-furanose decreased by 60-80% the reactivity of sera from PCM patients with Band 1, suggesting that this residue is immunodominant. With the presumed absence of galactofuranose in mammalian hosts, compounds containing this residue may be useful targets for therapy of several parasitic and fungal diseases.
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