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  • Title: The gut associated addressins: lymphocyte homing in the gut.
    Author: De Keyser F, Elewaut D, De Wever N, Bensbaho K, Cuvelier C.
    Journal: Baillieres Clin Rheumatol; 1996 Feb; 10(1):25-39. PubMed ID: 8674147.
    Abstract:
    The process of lymphocyte trafficking is mainly regulated by receptors that belong to a group of molecules referred to as adhesion molecules. These molecules can be divided, according to their molecular structure, into three broad families: the integrins; the selectins; and the immunoglobulin superfamily members. The alpha 4 beta 7 integrin is expressed on some lymphocytes with hallmarks of gut tropism. alpha 4 beta 7, among others, serves as a ligand for the mucosal vascular addressin MadCAM-1, which is selectively expressed on mucosal lymphoid organ high endothelial venules and on gut lamina propria venules. It is tempting to believe that related integrin receptors play a crucial role in the recirculation of activated lymphocytes between the gut mucosa and the synovial membrane.
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