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  • Title: The effect of roxithromycin on the generation of reactive oxygen species in vitro.
    Author: Akamatsu H, Nishijima S, Akamatsu M, Kurokawa I, Sasaki H, Asada Y.
    Journal: J Int Med Res; 1996; 24(1):27-32. PubMed ID: 8674797.
    Abstract:
    The effect of roxithromycin (ROM), a new oral semi-synthetic macrolide, on the generation of reactive oxygen species (ROS), using human neutrophils and a cell-free, xanthine-xanthine oxidase system was examined. The species investigated were the superoxide radical anion (O2-), hydrogen peroxide (H2O2), and the hydroxyl radical (OH.). ROM effectively inhibited the generation of O2-, H2O2 and OH. by human neutrophils. On the other hand, the drug did not markedly affect the ROS levels generated in the xanthine-xanthine oxidase system. The present study indicates that ROM may exert an anti-inflammatory action by inhibiting neutrophil oxygen radical generation at the sites of inflammation.
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