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  • Title: Preclinical animal studies with radioiododeoxyuridine.
    Author: Kassis AI, Adelstein SJ.
    Journal: J Nucl Med; 1996 Apr; 37(4 Suppl):10S-12S. PubMed ID: 8676195.
    Abstract:
    UNLABELLED: We examined the diagnostic and therapeutic potential of 5-iodo-2'- deoxyuridine (IUdR) radiolabeled with the Auger electron emitters 123I and 125I in several animal tumor models. METHODS: Experiments were conducted using mice bearing an intraperitoneal ovarian tumor (*IUdR by intracavitary injection), and rats bearing either bladder cancer (*IUdR by intravesical injection), brain gliosarcomas (intratumoral injection), or intrathecal gliosarcomas (intrathecal injection). RESULTS: After locoregional administration, [123I]IUdR and [125I]IUdR localize within tumor, clear rapidly from the rest of the body and are therapeutically effective. CONCLUSION: When labeled with the Auger electron emitter 123I or 125I, IUdR demonstrates therapeutic efficacy. In addition, [123I]IUdR has a potential role in the scintigraphic detection of cancer.
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