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  • Title: [Lung disease induced by isotretinoin].
    Author: Oliviero G, Constans P, Caby I, De Rohan Chabot P, Lacherade JC.
    Journal: Rev Mal Respir; 1995; 12(6):631-3. PubMed ID: 8677360.
    Abstract:
    A young man without any past history of note had taken isotretinoin for disfiguring acne before the summer season. He presented with a severe bilateral pneumonia, associated with dyspnoea two months after the start of treatment. On the pulmonary radiography there was a bilateral ground glass appearance which was worse on the right. The elevated level of eosinophils (54% in 564,000 cells/ml) in the alveolar lavage lead to a diagnosis of allergic pneumonia. The rapidly favourable outcome following the cessation of the medication and with the addition of corticosteroids seemed to us a supplementary argument in favour of a diagnosis of eosinophilic pneumonia, due to isotretinoin which seemed the primary initiating factor.
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