These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [In vitro chemosensitivity test for seven undifferentiated thyroid carcinoma cell lines using MTT assay].
    Author: Osawa Y, Yoshida A, Asaga T, Kawahara S, Yanoma S.
    Journal: Gan To Kagaku Ryoho; 1996 Mar; 23(4):471-6. PubMed ID: 8678500.
    Abstract:
    In the current study, we ran a chemosensity test on 7 human undifferentiated carcinoma cell lines against 10 anticancer compounds using MTT assay. Efficacy was estimated by comparing fifty percent inhibitory concentration (IC50) with the peak plasma concentration. The results showed that the 7 cell lines could be divided into two groups which had different (high or low) chemosensitivity, and that in the high sensitivity group, ACD, VCR, and etoposide were indicated as useful drugs. Our results suggest that it may be impossible to rescue all undifferentiated carcinoma patients by chemotherapy alone because the tumor may consist of 2 clones which have a different chemosensitivity.
    [Abstract] [Full Text] [Related] [New Search]