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Title: [DNA ploidy pattern in resected human hepatocellular carcinomas from the view point of biological malignant potential].
Author: Saiki I, Une Y, Shimamura T, Uchino J.
Journal: Gan To Kagaku Ryoho; 1996 Jun; 23 Suppl 2():135-42. PubMed ID: 8678556.
Abstract:
Nuclear DNA ploidy analysis was studied in patients with hepatocellular carcinoma (HCC) who underwent hepatic resections. These patients were classified three groups according to the following prescriptions. Group A (n = 100) was a group of patients of which excluded ones treated by absolute non-curative resection, Group B (n = 43) was patients who underwent absolute curative resection or relative curative resection, and Group C (n = 81) was patients whose tumor sizes were more than 2 cm in Group A. Aneuploid pattern was found in 59 cases (59.0%) in Group A, 22 cases (51.2%) in Group B and 54 cases (66.7%) in Group C. The rate of aneuploid pattern was significantly higher in patients with carcinomas more than 2 cm in diameter, fc-inf positive growth, Stage III + IV and PCNA LI > or = 40% in Group A, those with carcinomas more than 2 cm in diameter, fc-inf positive growth, im-positive and Stage III + IV in Group B, and those with PCNA LI > or = 40% in Group C. The postoperative prognoses of patients with aneuploid pattern in Group A and Group C were significantly poorer than those of the diploid one in cumulative survival rates and survival rates after recurrence. Patients with aneuploid pattern in Group B had a poorer prognosis than those with diploid one in cumulative survival rates and disease-free survival rates. These results suggest that nuclear DNA ploidy analysis was a useful marker of biological malignant potential in resected human HCCs.

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