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  • Title: Adsorption behavior of serum albumin on electrode surfaces and the effects of electrode potential.
    Author: Guo B, Anzai J, Osa T.
    Journal: Chem Pharm Bull (Tokyo); 1996 Apr; 44(4):800-3. PubMed ID: 8681412.
    Abstract:
    The adsorption behavior of serum albumin onto the surface of platinum, gold, and glassy carbon electrodes was studied in relation to the electrode potential, by using cyclic voltammetry and a quartz-crystal microbalance. The kinetics of adsorption was significantly dependent on the electrode potential. The adsorption was highly accelerated by the application of positive potential to the electrode, suggesting an electrostatic interaction between the negatively charged albumin molecules and the positively polarized electrode as the origin of the accelerated adsorption. The adsorption of albumin on the electrodes was irreversible with respect to dilution of the albumin solution, while the quartz-crystal microbalance data showed that albumin forms a monomolecular layer on the electrode surface. Protein adsorption on electrode surface in serum was also examined.
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