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  • Title: Carcinosarcoma of the liver with mesenchymal differentiation: a case report.
    Author: Leger-Ravet MB, Borgonovo G, Amato A, Lemaigre G, Franco D.
    Journal: Hepatogastroenterology; 1996; 43(7):255-9. PubMed ID: 8682474.
    Abstract:
    Carcinosarcoma of the liver with mesenchymal differentiation are very rare in adult patients. A case is reported with an exhaustive pathologic examination and review of the literature. A 61-year old man presented with general fatigue and dull abdominal pain. Two liver masses were diagnosed and resected by a right hepatectomy. Specimen pathology revealed that the tumor and lymph node consisted of two cancerous components. One carcinomatous component corresponding to a hepatocellular carcinoma and a sarcomatous component characterized by a diffuse proliferation of spindle shaped cells with chondrosarcomatous and osteosarcomatous changes. Patient died 9 months later of a diffusion of the tumor. For the first time, to our knowledge, a mesenchymal differentiation is demonstrated in liver carcinosarcoma.
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