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  • Title: Protective antibodies in murine Lyme disease arise independently of CD40 ligand.
    Author: Fikrig E, Barthold SW, Chen M, Grewal IS, Craft J, Flavell RA.
    Journal: J Immunol; 1996 Jul 01; 157(1):1-3. PubMed ID: 8683101.
    Abstract:
    Borrelia burgdorferi-infected mice develop acute arthritis that undergoes Ab-mediated resolution. To further investigate the role of B. burgdorferi-specific Abs in Lyme borreliosis, CD40 ligand-deficient (CD40L-deficient) mice were infected with B. burgdorferi. The development and regression of arthritis were similar in CD40L-deficient and control mice. Although CD40L-deficient mice have defects in Ig class switching, infected CD40L-deficient mice developed B. burgdorferi-specific IgG2b Abs. Moreover, the transfer of serum from B. burgdorferi-infected CD40L-deficient animals prevented infection in severe combined immunodeficient mice. These data show that B. burgdorferi-infected CD40L-deficient mice are capable of producing Abs that are protective, despite the inability of these mice to mediate T-dependent immune responses.
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