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  • Title: Growth hormone response to growth hormone releasing hormone in non-delusional and delusional depression and healthy controls.
    Author: Contreras F, Navarro MA, Menchon JM, Rosel P, Serrallonga J, Perez-Arnau F, Urretavizcaya M, Vallejo J.
    Journal: Psychol Med; 1996 Mar; 26(2):301-7. PubMed ID: 8685286.
    Abstract:
    Growth hormone (GH) responses to growth hormone releasing hormone (GHRH) of 53 in-patients meeting DSM-III-R criteria for major depressive episode with melancholia (24 non-delusional and 23 delusional depression) were compared with those of 19 healthy controls. No significant differences in basal GH were found between the control and either the non-delusional or the delusional groups. The whole group of depressed patients showed a significantly lower response than the control patients at all points of the GH response to GHRH curve as well as a lower area under curve. When the three groups (control, delusional, and non-delusional depressed) were compared, it was found that only the non-delusional depressed patients had a significantly lower area under curve and lower values at +60, +90 and +120 min than the controls. The only significant difference between the two groups of depressed patients was that the delusional group showed a delayed appearance of the maximum response peak and a more prolonged response.
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