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  • Title: Macrophage cytotoxicity against murine meth A sarcoma involves nitric oxide-mediated apoptosis.
    Author: Sveinbjørnsson B, Olsen R, Seternes OM, Seljelid R.
    Journal: Biochem Biophys Res Commun; 1996 Jun 25; 223(3):643-9. PubMed ID: 8687449.
    Abstract:
    We have studied the cytotoxic effect of stimulated macrophages on Meth A tumor cells in vitro. When stimulated with interferon-gamma and soluble beta-1,3-D-glucan, macrophages exerted cytotoxicity towards syngeneic Meth A tumor cells. This cytotoxicity was associated with a high level of nitric oxide production. Both cell death and nitric oxide production were significantly inhibited by the addition of aminoguanidine, a specific inhibitor of inducible nitric oxide synthase (iNOS), to the culture medium. The cytotoxic effect was accompanied by internucleosomal cleavage of DNA as shown by electrophoresis and DNA fragmentation assay.
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